Hepatic and reproductive toxicity of sub-chronic exposure to dichlorvos and lead acetate on male Wistar rats
作者机构：Department of PhysiologySchool of Basic Medical SciencesIgbinedion UniversityOkadaEdo StateNigeria Department of PhysiologyUniversity of Medical SciencesOndo-CityOndo StateNigeria Department of Pharmacology and PhysiologyAdeleke UniversityEdeOsun StateNigeria
出 版 物：《Asian pacific Journal of Reproduction》 (亚太生殖杂志（英文版）)
年 卷 期：2020年第9卷第6期
页 面：283-290页
学科分类：0710[理学-生物学] 1002[医学-临床医学] 0905[农学-畜牧学] 0906[农学-兽医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 0901[农学-作物学] 0902[农学-园艺学] 10[医学]
主 题：Dichlorvos Lead acetate Androgen receptors Pituitary testicular axis
摘 要：Objective:To investigate the hepatic and reproductive toxicity of dichlorvos and lead acetate on male Wistar ***:Fifteen adult male Wistar rats(170-190 g)were randomly divided into three groups,with 5 rats in each *** 1 received 0.5 mL distilled water orally and served as the control group,while groups 2 and 3 were orally treated with 2 mg/kg body weight(b.w.)dichlorvos and 10 mg/kg *** acetate,respectively,for 55 *** sperm,serum follicle stimulating hormone(FSH),luteinizing hormone(LH),testosterone concentrations,testicular 17β-hydroxysteroid dehydrogenase activity(17β-HSD),androgen receptor expression,aspartate aminotransferase(AST),alanine aminotransferase(ALT),testicular oxidant and antioxidant enzymes were evaluated with standard ***:Sperm count,motility,morphology,FSH,LH,testosterone levels,17β-HSD,androgen receptor expression,and catalase activity were significantly reduced in the dichlorvos and lead acetate treated groups as compared with the control group(P0.05).The liver AST,ALT activities and malondialdehyde concentration were significantly increased in the dichlorvos and lead acetate treated groups as compared with the control group(P0.05).Conclusions:The reproductive and hepatic toxicity activities of dichlorvos and lead acetate in male Wistar rats are similar.
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