The role of intestinal microbiota,bile acids,and Th17/IL17 axis in hepatitis B virus-related liver fibrosis

作     者：Yan-Fei Chen Jiu Chen Lan-Juan Li Chen Yan-Fei;Chen Jiu;Li Lan-Juan

作者机构：State Key Laboratory for Diagnosis and Treatment of Infectious DiseasesNational Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesDepartment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang 310003China Department of Traditional Chinese MedicineThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang 310003China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2020年第133卷第24期

页      面：2902-2904页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：Th17 bile IL17 

摘      要：Hepatitis B virus(HBV)infection,which affects 90 million people in China,remains a prominent cause of liver cancer and liver cirrhosis.[1]Chronic HBV infection has a complicated course,which is a dynamic process formed by the interaction between the virus and the immune system.[2,3]Hepatic fibrosis is the basis of liver cirrhosis and liver cancer.[4]In recent years,accumulating studies have indicated potential roles of intestinal microbiota,bile acids,and T helper(Th)17/interleukin(IL)-17 axis in the process of HBV-related liver *** microbiota actively communicates with bile acids and plays an important role in the pathogenesis of HBV-related liver *** the following content,we are going to summarize current evidence of the role of intestinal microbiota,bile acids,and Th17/IL-17 axis in HBV-related liver fibrosis.