Immobility Responses Affected by Potassium in Old Rats

作     者：Linda Garces-Ramirez Oscar OMorales-Dionisio Gonzalo Flores JoseLuna-Munoz Fidel de la Cruz Linda Garcés-Ramírez;Oscar O. Morales-Dionisio;Gonzalo Flores;José Luna-Muñoz;Fidel de la Cruz

作者机构：Departamento de Fisiologia“Mauricio Russek Berman”Escuela Nacional de Ciencias BiologicasInstituto Politecnico NacionalCiudad de MexicoMexico Laboratorio de NeuropsiquiatriaInstituto de FisiologiaBenemerita Universidad Autonoma de PueblaPueblaMexico National Dementia BioBankCiencias BiologicasFacultad de Estudios SuperioresCuautitlanUNAMEstado de MexicoMexico Banco Nacional de Cerebros-UNPHUUniversidad Nacional Pedro Hernriquez UrenaSanto DomingoRepublica Dominicana 

出 版 物：《Pharmacology & Pharmacy》 (药理与制药（英文）)

年 卷 期：2020年第11卷第9期

页      面：235-250页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Immobility Responses (IR) Potassium Spironolactone Hyperkalemia Familial Periodic Paralysis 

摘      要：Four immobility responses (IR): elicited by clamping, bandaging, grasping and inversion, and their modification by potassium and spironolactone was studied in old Wistar rats (body weight, 500 g). When undrugged, only clamping and grasping, but not bandaging and inversion induced an IR in rats. Potassium and spironolactone significantly enhanced the duration of IR induced by clamping but not by grasping. They also induced an immobility response by bandaging, but not by inversion. The data suggest that IR induced by clamping and bandaging are somehow related to changes in the potassium serum levels. Consequently, such a relationship may be a suitable model to study some forms of paralysis in human beings which are related to changes in the potassium serum levels.