Anxiolytic Effect of Increased NREM Sleep after Acute Social Defeat Stress in Mice

作     者：Xiang Feng Hui-Ying Zhao Yu-Jin Shao Hui-Fang Lou Li-Ya Zhu Shumin Duan Yan-Qin Yu Xiang Feng;Hui-Ying Zhao;Yu-Jin Shao;Hui-Fang Lou;Li-Ya Zhu;Shumin Duan;Yan-Qin Yu

作者机构：Department of Neurobiology and Department of Neurology of The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2020年第36卷第10期

页      面：1137-1146页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：This work was supported by the National Key Research and Development Program of China(2016YFA0501000 and 2016YFC1306700) the National Natural Science Foundation of China(31970939,81527901,81821091,31771167,31571090,and 31490592) the Science and Technology Planning Project of Guangdong Province of China(2018B030331001) the Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences(2018PT31041) and Fundamental Research Funds for the Central Universities,China(2017FZA7003). 

主　　题：Social defeat stress Sleep Sleep deprivation Anxiety Anxiolytic effect 

摘      要：Social defeat stress(SDS)plays a major role in the pathogenesis of psychiatric disorders like anxiety and depression.Sleep is generally considered to involve recovery of the brain from prior experience during wakefulness and is altered after acute SDS.However,the effect of acute SDS on sleep/wake behavior in mice varies between studies.In addition,whether sleep changes in response to stress contribute to anxiety is not well established.Here,we first investigated the effects of acute SDS on sleep/wake states in the active period in mice.Our results showed that total sleep time(time in rapid eyemovement[REM]and non-REM[NREM]sleep)increased in the active period after acute SDS.NREM sleep increased mainly during the first 3 h after SDS,while REM sleep increased at a later time.Then,we demonstrated that the increased NREM sleep had an anxiolytic benefit in acute SDS.Mice deprived of sleep for 1 h or 3 h after acute SDS remained in a highly anxious state,while in mice with ad libitum sleep the anxiety rapidly faded away.Altogether,our findings suggest an anxiolytic effect of NREM sleep,and indicate a potential therapeutic strategy for anxiety.