Enlisting a Traditional Chinese Medicine to tune the gelation kinetics of a bioactive tissue adhesive for fast hemostasis or minimally invasive therapy
作者机构：Key Laboratory for Ultrafine Materials of Ministry of EducationFrontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Material Science and EngineeringEast China University of Science and TechnologyShanghai200237China Department of Cardiothoracic SurgeryShanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong University1678 Dong Fang RoadShanghai200127China
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2021年第6卷第3期
页 面：905-917页
核心收录：
学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术]
基 金：supported by National Natural Science Foundation of China(grant number:31922041,51621002,11932012 , 21875066) the science and technology innovation project of Shanghai Science and Technique Committee(18441908300) the Fundamental Research Funds for the Central Universities(SLD 00202006,JKVD12001032,JKVD12001002,50321041916015)
主 题：Injectable tissue adhesive Gelation time Borax Rapid hemostasis Minimally invasive delivery
摘 要：Gelation kinetics is important in tailoring chemically crosslinked hydrogel-based injectable adhesives for different ***,the regulation of gelation rate is usually limited to varying the gel precursor and/or crosslinker concentration,which cannot reach a fine level and inevitably alters the physical properties of *** reactions are widely used to synthesize hydrogel *** this work,we propose a traditional Chinese medicine(Borax)-input strategy to tune the gelation rate of amidation reaction triggered *** provides an initial basic buffer environment to promote the deprotonation process of amino groups and accelerate this *** using a tissue adhesive model PEG-lysozyme(PEG-LZM),the gelation time can be modulated from seconds to minutes with varying Borax concentrations,while the physical properties remain ***,the antibacterial ability can be improved due to the bioactivity of *** hydrogel precursors can be regulated to solidify instantly to close the bleeding wound at ***,they can also be customized to match the flowing time in the catheter,thereby facilitating minimally invasive tissue *** this method is easily operated,we envision Borax adjusted amidation-type hydrogel has a promising prospect in clinical application.
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