The beneficial effects of intermittent fasting:an update on mechanism,and the role of circadian rhythm and gut microbiota
作者机构：Department of Liver SurgerySun Yat-Sen University Cancer CenterGuangzhouChina Department of SurgeryPeking Union Medical College HospitalBeijingChina Department of Clinical BiochemistryFaculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Saudi Diabetes Study Research Group(SDRG)-King Fahd Medical Research CentreKing Abdulaziz UniversityJeddahSaudi Arabia
出 版 物：《Hepatobiliary Surgery and Nutrition》 (肝胆外科与营养（英文）)
年 卷 期：2020年第9卷第5期
页 面：597-602页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Intermittent fasting(IF) circadian rhythm gut microbiota
摘 要：Importance:There is accumulating evidence that intermittent fasting(IF)is connected to improved health condition and longevity time-restricted feeding(TRF)is the most recognized and extensively studied model of ***:To investigate the underlying mechanism of pleiotropic benefits of IF and hint the most advantageous feeding pattern for *** review:We searched MEDLINE,EMBASE,Cochrane Library and Google Scholar by 2020 April for publications on IF or TRF and their *** include animal models and human ***:One important mechanism is that IF allows certain period of fasting time,in which our bodies activate pathways of repair and ***,the advantages of IF,especially TRF over total caloric restriction(CR)provided bases for various animal and human studies which suggested that the feeding-fasting rhythm stimulates the fluctuation of our gut microbiota and a series of subsequent molecular alterations,which in turn restored a healthier circadian clock that resembled our inherent clock formed throughout millions of years of homo sapiens *** and Relevance for Reviews:Complete understanding of the mechanism leading to the beneficial effects of IF paves the way for tailored dietary regimen to combat a wide range of diseases and ill health conditions.
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