Ubiquitination modification:critical regulation of IRF family stability and activity

作     者：Bao-qin Liu Jin Jin Yi-yuan Li Bao-qin Liu;Jin Jin;Yi-yuan Li

作者机构：Key Laboratory for Developmental Genes and Human DiseaseMinistry of EducationInstitute of Life SciencesJiangsu Province High-Tech Key Laboratory for Bio-Medical ResearchSoutheast UniversityNanjing 210096China MOE Laboratory of Biosystem Homeostasis and Protectionand Life Sciences InstituteZhejiang UniversityHangzhou 310058China Sir Run Run Shaw HospitalCollege of Medicine Zhejiang UniversityHangzhou 310016China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2021年第64卷第6期

页      面：957-965页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 

基　　金：supported by the National Key Research and Development Program of China(2018YFA0800503 and 2018YFD0500100) an excellent young scientist foundation of NSFC(31822017) Zhejiang Provincial Natural Science Foundation of China(LR19C080001) the National Natural Science Foundation of China(81572651 and 81771675) the Fundamental Research Funds for the Central Universities 

主　　题：IRFs ubiquitination E3 ubiquitin ligase viral proteins activation degradation 

摘      要：Interferon regulatory factors(IRFs)play pivotal and critical roles in innate and adaptive immune responses;thus,precise and stringent regulation of the stability and activation of IRFs in physiological processes is *** stability and activities of IRFs are directly or indirectly targeted by endogenous and exogenous proteins in an ubiquitin-dependent ***,few reviews have summarized how host E3 ligases/DUBs or viral proteins regulate IRF stability and ***,with recent technological developments,details about the ubiquitination of IRFs have been continuously *** knowledge of how these proteins function and interact with IRFs may facilitate a better understanding of the regulation of IRFs in immune responses or other biological processes,we summarized current studies on the direct ubiquitination of IRFs,with an emphasis on how these proteins interact with IRFs and affect their activities,which may provide exciting targets for drug development by regulating the functions of specific E3 ligases.