Catalysis-based specific detection and inhibition of tyrosinase and their application

作     者：Yunwei Qu Qing Zhan Shubo Du Yang Ding Bin Fang Wei Du Qiong Wu Haidong Yu Lin Li Wei Huang Yunwei Qu;Qing Zhan;Shubo Du;Yang Ding;Bin Fang;Wei Du;Qiong Wu;Haidong Yu;Lin Li;Wei Huang

作者机构：Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM)Nanjing Tech University(NanjingTech)NanjingPR China Department of ChemistryNational University of SingaporeSingapore Frontiers Science Center for Flexible ElectronicsXi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical University127 West Youyi RoadXi’an710072China 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2020年第10卷第5期

页      面：414-425页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：This work was financially supported by the National Natural Science Foundation of China(81672508,21675085) Jiangsu Provincial Foundation for Distinguished Young Scholars(BK20170041,BK20170042) the Joint Research Funds of Department of Science&Technology of Shaanxi Province and Northwestern Polytechnical University(2020GXLH-Z-008,2020GXLH-Z-023) the Natural Science Basic Research Programof Shaanxi(Program No.2019JM-016) Key Research and Development Program of Shaanxi(2020ZDLGY13-04) Open Research Fund of Anhui Key Laboratory of Tobacco Chemistry(20181140) China-Sweden Joint Mobility Project(51811530018) Fundamental Research Funds for the Central Universities 

主　　题：Tyrosinase Melanin Detection probe Inhibitors Melanoma 

摘      要：Tyrosinase is an important enzyme in controlling the formation of melanin in melanosome,and plays a key role in the pigmentation of hair and *** abnormal expression or activation of tyrosinase is associated with several diseases such as albinism,vitiligo,melanoma and Parkinson *** deposition of melanin could cause diseases such as freckles and brown spots in the human body,and it is also closely related to browning of fruits and vegetables and insect *** and inhibiting the activity of tyrosinase is of extraordinary value in the progress of diagnosis and treatment of these ***,many selective optical detection probes and small molecular inhibitors have been developed,and have made significant contributions to the basic and clinical research on these *** this paper,the detection and inhibition of tyrosinase and their application in whitening products are reviewed,with special emphasis on development of fluorescent probes and ***,this review will help design more efficient and sensitive tyrosinase probes and inhibitors,as well as shed light on novel treatment of diseases such as melanoma.