The association of grip strength with cardiovascular diseases and all-cause mortality in people with hypertension:Findings from the Prospective Urban Rural Epidemiology China Study

作     者：Weida Liu Darryl P Leong Bo Hu Lap AhTse Sumathy Rangarajan Yang Wang Chuangshi Wang Fanghong Lu Yindong Li Salim Yusuf Lisheng Liu Wei Li Weida Liu;Darryl P Leong;Bo Hu;Lap AhTse;Sumathy Rangarajan;Yang Wang;Chuangshi Wang;Fanghong Lu;Yindong Li;Salim Yusuf;Lisheng Liu;Wei Li

作者机构：Medical Research&Biometrics CenterFuwai HospitalNational Center for Cardiovascular DiseasesPeking Union Medical College&Chinese Academy of Medical SciencesBeijing 102300China The Population Health Research InstituteMcMaster University and Hamilton Health SciencesHamiltonONL8S4L8Canada Jockey Club School of Public Health and Primary CareFaculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Cardio-Cerebrovascular Control and Research CenterInstitute of Basic MedicineShandong Academy of Medical SciencesJinan 250002China Shunyi Center for Disease Control and PreventionBeijing 101300China 

出 版 物：《Journal of Sport and Health Science》 (运动与健康科学（英文）)

年 卷 期：2021年第10卷第6期

页      面：629-636,F0003页

核心收录：

学科分类：0403[教育学-体育学] 040302[教育学-运动人体科学(可授教育学、理学、医学学位)] 04[教育学] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Canadian Institutes of Health Research, Heart and Stroke Foundation of Ontario HHSRI Hamilton Health Sciences Research Institute National Center for Cardiovascular Diseases Population Health Research Institute ThinkTank Research Center for Health Development 

主　　题：Cardiovascular disease Cohort study Grip strength Hypertension Mortality 

摘      要：Background:Both hypertension and grip strength(GS)are predictors of mortality and cardiovascular disease(CVD),but whether these risk factors interact to affect CVD and all-cause mortality is *** study sought to investigate the associations of GS with the risk of major CVD incidence,CVD mortality,and all-cause mortality in patients with ***:GS was measured using a Jamar dynamometer(Sammons Preston,Bolingbrook,IL,USA)in participants aged 35
70 years from 12 provinces included in the Prospective Urban Rural Epidemiology China *** frailty proportional hazards models were used to examine the associations of GS and hypertension and the outcomes of all-cause mortality and CVD incidence/***:Among 39,862 participants included in this study,15,964 reported having hypertension,and 9095 had high GS at *** a median follow-up of 8.9 years(interquartile range,6.7
9.9 years),1822 participants developed major CVD,and 1250 deaths occurred(388 as a result of CVD).Compared with normotensive participants with high GS,hypertensive patients with high GS had a higher risk of major CVD incidence(hazard ratio(HR)=2.39;95%confidence interval(95%CI):1.86
3.06;p0.001)or CVD mortality(HR=3.11;95%CI:1.59
6.06;p0.001)but did not have a significantly increased risk of all-cause mortality(HR=1.24;95%CI:0.92
1.68;p=0.159).These risks were further increased if hypertensive participants whose GS level was low(major CVD incidence,HR=3.31,95%CI:2.60
4.22,p0.001;CVD mortality,HR=4.99,95%CI:2.64
9.43,p0.001;and all-cause mortality,HR=1.93,95%CI:1.47
2.53,p0.001).Conclusion:The present study demonstrates that low GS is associated with the highest risk of major CVD incidence,CVD mortality,and all-cause mortality among hypertensive *** levels of GS appear to mitigate long-term mortality risk among hypertensive patients.