Two Cu(Ⅱ)and Co(Ⅱ)-based Coordination Polymers Based on the N,S-donor Ligand:Crystal Structures and Anticancer Activity Evaluation

作     者：李靖 李江涛 LI Jing;LI Jiang-Tao

作者机构：Key Laboratory for Surface Engineering and Remanufacturing in Shaanxi ProvinceSchool of Chemical EngineeringXi'an UniversityXi'an 710065China 

出 版 物：《Chinese Journal of Structural Chemistry》 (结构化学（英文）)

年 卷 期：2020年第39卷第10期

页      面：1849-1854,1744页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 10[医学] 

基　　金：the Industrial Research Project of Science and Technology Department of Shaanxi Province(No.2017GY-126) 

主　　题：coordination polymer N S-donor ligand CCK-8 assay anticancer activity 

摘      要：Two new Cu(II)and Co(II)-based coordination polymers with the chemical formulae of{Cu(L)2]·DMF}n(1)and{[Co(L)2]·2DMF}n(2)have been successfully constructed from a pyridine-substituted N-heterocyclic thioamide ligand,namely[3,4?-bipyridine]-2?-thiol(HL).Complex 1 is composed of two identical coordination networks with dia topology interpenetrating into each other,and shows 1-D microporous channels along the a *** 2 is assembled by 2-D square-grid layers stacked in an eclipsed fashion to give 1-D large square channels along the b ***-8 was used for the detection of cancer *** indicated that compound 1 exhibited stronger anti-cancer activity than compound 2 on the H1650 cancer *** Annexin V-FITC/PI was recommended for cancer cell apoptosis,and the western blot was applied for the detection of PI3K/AKT pathway activation.