Chiral nanoparticle-induced amplification in optical activity of molecules with chiral centers

作     者：Lin Yang Junjun Liu Junhong Deng Zhifeng Huang 

作者机构：Department of PhysicsHong Kong Baptist University(HKBU)Hong KongChina HKBU Institute of Research and Continuing EducationShenzhen Virtual University ParkShenzhenChina Department of Materials Science and EngineeringSouthern University of Science and TechnologyShenzhen Institute for Quantum Science and EngineeringShenzhenChina State Key Laboratory of Environmental and Biological AnalysisGolden Meditech Centre for NeuroRegeneration SciencesInstitute of Advanced MaterialsHong KongChina 

出 版 物：《InfoMat》 (信息材料（英文）)

年 卷 期：2020年第2卷第6期

页      面：1216-1224页

核心收录：

学科分类：0808[工学-电气工程] 081704[工学-应用化学] 0809[工学-电子科学与技术（可授工学、理学学位）] 07[理学] 0817[工学-化学工程与技术] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 070303[理学-有机化学] 0703[理学-化学] 0702[理学-物理学] 

基　　金：GRF,Grant/Award Number:12200118 National Natural Science Foundation of China,Grant/Award Number:91856127 SKLP,Grant/Award Number:1920_P06 

主　　题：(2'R,3'R,4'S)-riboflavin-5'-phosphate sodium salt chiral nanoparticles circular dichroism glancing angle deposition optical activity 

摘      要：Sensitive differentiation of an enantiomer from its mirror image(ie,enantiodifferentiation),a perennial challenge for pharmaceutical production and disease diagnosis,is technically limited by the weak optical activity(OA)of enantiomers,mainly due to their dimensional mismatch with light wavelengths in the ultraviolet(UV)-visible *** we use silver chiral nanoparticles(Ag CNPs)with nominally sub-5 nm helical pitch(P)to amplify the OA of(20R,30R,40S)-riboflavin-50-phosphate sodium salts(RP),which have been found to indirectly affect metabolic processes,through the formation of an RP thin film(TF)covering a close-packed array of Ag *** OA of the RP in the deep-UV region can be amplified up to 80-fold,ascribed to the aggregation of RP in the TFs and the interactions between RP and the atomically chiral lattices at the CNPs *** former contribution,not associated with the chiral Ag topographies,plays a dominant role by thickening the RP TFs,so that the observed amplification has no enantioselective dependence on the chirality of the Ag *** study extends progress in the sensitive detection of bio-enantiomers,which is highly desired for advanced bio-detection in disease diagnosis and production of single-enantiomer pharmaceuticals.