Analysis of Clinicopathological Characteristics and Prognosis of Young Patients with Hepatocellular Carcinomaafter Hepatectomy

作     者：Chuan Li Kang Chen Xu Liu Hao-Tian Liu Xiu-Mei Liang Guang-Lan Liang Shao-Tong Tang Rong-Rui Huo Liang Ma Bang-Be Xiang Jian-Hong Zhong Le-Qun Li Chuan Li;Kang Chen;Xu Liu;Hao-Tian Liu;Xiu-Mei Liang;Guang-Lan Liang;Shao-Tong Tang;Rong-Rui Huo;Liang Ma;Bang-Be Xiang;Jian-Hong Zhong;Le-Qun Li

作者机构：Hepatobiliary Surgery DepartmentGuangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research CenterGuangxi Medical University Cancer HospitalNanningGuangxiChina 

出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)

年 卷 期：2020年第8卷第3期

页      面：285-291页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：partly supported by the Self-Raised Scientific Research Fund of the Ministry of Health of Guangxi Province(Z2016512,Z2015621,Z20200923) the Graduate Course Construction Project of Guangxi Medical University(YJSA2017014) the Guangxi Natural Science Foundation(2018GXNSFBA138018 and 2020GXNSFAA159022) the National Major Special Science and Technology Project(2017ZX10203207) the‘Guangxi BaGui Scholars’Special Fund 

主　　题：Hepatocellular carcinoma Hepatectomy Age Prognosis Overall survival Hepatitis B 

摘      要：Background and Aims:This study was designed to analyze the effects of age and clinicopathological characteristics on prognosis of Chinese patients with hepatocellular carcinoma(HCC).Methods:The clinical data of 2032 HCC patients who were first diagnosed with HCC and underwent curative hepatectomy in our hospital between January 2006 and January 2011 were retrospectively ***:Younger HCC patients(age40 years,n=465)had a significantly higher hepatitis B infection rate,larger tumors,higher alpha-fetoprotein levels,higher preoperative liver function,and more frequent vascular invasions than older *** younger patients were suitable for anatomical hepatectomy,and their tumors were found to be at a highly advanced *** recurrence-free survival and overall survival rates of younger HCC patients were significantly worse than those of older patients but this difference disappeared after propensity score *** analysis of pre-matched samples showed that age≤40 years was one of the independent risk factors associated with poor overall ***:Younger patients showed different clinicopathological characteristics than older patients,such as higher rates of hepatitis B infection and advanced *** recurrence-free survival and overall survival rates of younger HCC patients after hepatectomy may be similar to those of older patients.