Shifting hierarchy of the conjunctival florae in the patients employed a long-time topical fluoroquinolone
作者机构：The First Hospital of Xi'anthe First Affiliated Hospital of Northwest UniversityXi'an 710002Shaanxi ProvinceChina The Third Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510150Guangdong ProvinceChina
出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)
年 卷 期：2020年第13卷第10期
页 面：1554-1560页
核心收录：
学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学]
基 金：Supported by the National Natural Science Foundation of China(No.81870631)
主 题：fluoroquinolone conjunctival flora antibiotic sensitivity virulence corneal ulcer
摘 要：AIM:To observe the shifting hierarchy of the conjunctival florae in the patients who employed a long-time topical fluoroquinolone and characterize the consequent variations of their antibiotic sensitivity and ***:A total of 143 eyes(143 patients)who suffered from the non-infectious corneal ulcer and topically used fluoroquinolone more than 2 wk were enrolled as the fluoroquinolone *** untreated fellow eye was considered as the contralateral ***-five healthy subjects were selected as the *** culture positivity and strains of the isolated conjunctival florae were *** antibiotic susceptibility and expression of the virulence-related genes were ***:Florae were recovered from 84.0%,37.1%,and 57.3%of the conjunctival swabs in the control,fluoroquinolone eye,and contralateral eye,*** most frequently isolated microorganisms were Staphylococcus epidermidis(34.9%)in the control,followed by Staphylococcus aureus(17.5%),Staphylococcus saprophyticus(14.3%),Micrococcus(9.5%),Propionibacterium acnes(7.9%).However,those orderly ranks shifted to Staphylococcus aureus(34.0%),Propionibacterium acnes(20.8%),Candida albicans(17.0%),Pseudomonas aeruginosa(9.4%)in the fluoroquinolone eye.A growing number of the fluoroquinolone-resistant florae survived in the fluoroquinolone eye,accompanied by an increased expression of the virulence-related ***:A long-time topical fluoroquinolone leads to a shifting hierarchy of the conjunctival florae,accompanied by the consequent variations of the antibiotic sensitivity and virulence.
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