Advanced delivery strategies facilitating oral absorption of heparins

作     者：Guihua Fang Bo Tang 

作者机构：School of PharmacyNantong University19 Qixiu RoadNantong 226001China 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2020年第15卷第4期

页      面：449-460页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 10[医学] 100602[医学-中西医结合临床] 

基　　金：Supported by the Natural Science Fund for Colleges and Universities in Jiangsu Province(No.18KJB350009) the Natural Science Fund for Colleges and Universities in Jiangsu Province(No.17KJB350009) the Natural Science Foundation of Jiangsu Province(No.BK20170445). 

主　　题：Heparins Oral delivery Multiple obstacles Stability Intestinal epithelia permeability Lymphatic transport 

摘      要：Heparins show great anticoagulant effect with few side effects,and are administered by subcutaneous or intravenous route in clinics.To improve patient compliance,oral administration is an alternative route.Nonetheless,oral administration of heparins still faces enormous challenges due to the multiple obstacles.This review briefly analyzes a series of barriers ranging from poorly physicochemical properties of heparins,to harsh biological barriers including gastrointestinal degradation and pre-systemic metabolism.Moreover,several approaches have been developed to overcome these obstacles,such as improving stability of heparins in the gastrointestinal tract,enhancing the intestinal epithelia permeability and facilitating lymphatic delivery of heparins.Overall,this review aims to provide insights concerning advanced delivery strategies facilitating oral absorption of heparins.