Predictors of mortality among HIV-infected patients initiating anti retroviral therapy at a tertiary care hospital in Eastern India

作     者：Ananya Bhowmik Subhasis Bhandari Rajyasree De Subhasish Kamal Guha 

作者机构：Centre of Excellence in HIVSchool of Tropical Medicine108Chittaranjan AvenueKolkata 700073West BengalIndia 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2012年第5卷第12期

页      面：986-990页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：ART Albumin CD4 HIV India Mortality Predictors 

摘      要：Objective:To assess early mortality and identify its predictors among the ART naive HIV-infected patients initiating anti retroviral therapy(ART) available free of cost at the ART Centres. Methods:A retrospective cohort analysis of routinely collected programme data was done for assessing mortality of all ART naive adult patients who received first-line ART at a government tertiary care hospital in eastern India during 1st March 2009 and 28th February *** and multiple regression analyses of the baseline demographic,clinical and laboratory records using SPSS 15.0 were done to identify independent predictors of ***:The mortality rate at one year was estimated to be 7.66(95%CI 5.84-9.83) deaths/100 patient-years and more than 50%of the deaths occurred during first three months of ART initiation with a median time interval of 73 *** was the major cause of *** naive patients with baseline serum albumin 3.5 mg/dL were eight(OR 7.9;95%CI:3.8-16.5) at risk of death than those with higher serum albumin levels and patients with CD4 count I00 cells/μL were two times(OR 2.2; 95%CI:1.1-4.4) at risk of death compared to higher CD4 ***:Risk of mortality is increased when ART is initiated at advanced stages of immunosuppression denoted by low serum albumin levels and CD4 cell *** highlights the importance of early detection of HIV infection,early management of opportunistic infections including tuberculosis and timely initiation of the antiretroviral drugs in the resource-limited countries,now available free in the Indian national ART programme.