Prodrugs incorporated into nanotechnology-based drug delivery systems for possible improvement in bioavailability of ocular drugs delivery

作     者：Tiantian Ye Kun Yuan Wenji Zhang Shuangshuang Song Fen Chen Xinggang Yang Shujun Wang Jianwei Bi Weisan Pan 

作者机构：School of PharmacyShenyang Pharmaceutical UniversityShenyang 110016China Shangdong Wego Pharmaceutical Co.LtdWeihai 264209China 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2013年第8卷第4期

页      面：207-217页

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：special construction projects fund which belongs to“Taishan Scholar-Pharmacy Specially Recruited Experts” 

主　　题：Ocular/ophthalmic drug delivery Prodrugs Nanocarriers Penetration Precorneal retention Bioavailability 

摘      要：Numerous systems have been designed during the past three decades to improve bioavailability of ophthalmic drug delivery,including:ocular prodrugs and nanotechnology-based drug delivery *** former can improve the efficacy of ocular drug via enhancing corneal penetration of ocular drugs,prolonging their duration of action and/or reducing the systemic side-effects,unfortunately,some characteristics of the pro-drugs,such as poorly aqueous stability,poorly aqueous solubility and severe eye irritation probably,limit their clinical practice and cannot be *** we all know,nanotech-nology for ocular drug delivery can carry poorly soluble drugs,protect the encapsulated molecules from hydrolysis,control the rate of drug delivery and prolong the precorneal retention of *** of these merits may solve the problems in the utilization of ocular prodrugs and increase the bioavailability of ocular drug *** reviewing recent ad-vances of prodrugs and nanostructures in ocular drug delivery,this paper focus specifically on the promising prospects of nanocarriers overcoming the drawbacks of prodrugs for ophthalmic drug delivery by precorneal routes.