Alginate-based complex fibers with the Janus morphology for controlled release of co-delivered drugs

作     者：Wing-Fu Lai Eric Huang Kwok-Ho Lui Wing-Fu Lai;Eric Huang;Kwok-Ho Lui

作者机构：School of Pharmaceutical SciencesShenzhen UniversityShenzhen 518060China School of Life and Health SciencesThe Chinese University of Hong Kong(Shenzhen)Shenzhen 518172China Department of Applied Biology and Chemical TechnologyHong Kong Polytechnic UniversityHong KongChina 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2021年第16卷第1期

页      面：77-85页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：funding support from the Science,Technology and Innovation Commission of Shenzhen Municipality(JCYJ20170818102436104) Natural Science Foundation of Guangdong Province(2018A030310485) the Chinese University of Hong Kong,Shenzhen(PF01001421) 

主　　题：Janus morphology Complex fiber Tunable release profiles Co-delivery Controlled release 

摘      要：Hydrogels are soft materials consisting of a three-dimensional network of polymer *** the years,hydrogels with different compositions have been developed as drug carriers for diverse biomedical applications,ranging from cancer therapy and wound care to the treatment of neurodegenerative and inflammatory *** of these carriers,however,are designed only to deliver single *** based on hydrogels for co-delivery of multiple agents,with the release rate of each of the co-delivered agents tunable,are *** study reports a one-pot method of fabricating alginate-based complex fibers with the Janus morphology,with carboxymethyl cellulose sodium functioning as a polymeric modifier of the properties of each of the fiber *** using malachite green and minocycline hydrochloride as model drugs,the generated fibers demonstrate the capacity of enabling the release profile of each of the co-delivered drugs to be precisely *** with their negligible toxicity and the retention of the activity of the loaded drugs,the complex fibers reported in this study warrant further development and optimization for applications that involve co-delivery of multiple agents.