Solubility and Thermodynamic Properties of Sulfamethazine-Saccharin Cocrystal in Pure and Binary (Acetonitrile + 2-Propanol) Solvents

作     者：Hongyuan Wei Ningcan Gao Leping Dang Hongyuan Wei;Ningcan Gao;Leping Dang

作者机构：School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China 

出 版 物：《Transactions of Tianjin University》 (天津大学学报（英文版）)

年 卷 期：2021年第27卷第6期

页      面：460-472页

核心收录：

学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 

基　　金：supported by the National Natural Science Foundation of China(No.21676196) 

主　　题：Sulfamethazine-saccharin cocrystal Solid-liquid equilibrium Thermodynamic model Dissolution thermodynamic property 

摘      要：In this work,a new crystallization method was used to prepare two polymorphs of sulfamethazine-saccharin(SMT-SAC)cocrystal in *** purity and crystal form of both polymorphs were confirmed by optical microscopy,scanning electron microscopy,powder X-ray diff raction,diff erential scanning calorimetry,and thermogravimetric ***,the solubility of the stable form(form Ⅱ)was determined by gravimetric analysis in nine pure solvents and one binary(acetoni-trile+2-propanol)solvent at temperatures ranging from 278.15 to 348.15 K at atmospheric *** data were correlated using the modified Apelblat model,theλh equation,the nonrandom two-liquid(NRTL)model,the Jouyban-Acree model,and the CNIBS/Redlich-Kister ***,the apparent thermodynamic properties,such asΔ_(dis)G,Δ_(dis) H,andΔ_(dis) S,were calculated on the basis of the activity coefficient obtained by the NRTL *** the models correlate well,and all the experimental and calculated results indicate that the dissolution behavior of SMT-SAC cocrystal form II is a spontaneous,endothermic,and entropy-driven process.