Preparation of carboxylmethylchitosan and alginate blend membrane for diffusion-controlled release of diclofenac diethylamine

作     者：Xiaoxue Yuan Ran Liu Wenchang Zhang Xiaoqiang Song Lei Xu Yan Zhao Lei Shang Jingsong Zhang Xiaoxue Yuan;Ran Liu;Wenchang Zhang;Xiaoqiang Song;Lei Xu;Yan Zhao;Lei Shang;Jingsong Zhang

作者机构：Shenyang National Laboratory for Materials ScienceInstitute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Materials Science and EngineeringUniversity of Science and Technology of ChinaHefei230026China School of PharmacyShenyang Medical CollegeShenyang110034China School of PharmacyShenyang Pharmaceutical UniversityShenyang110016China 

出 版 物：《Journal of Materials Science & Technology》 (材料科学技术（英文版）)

年 卷 期：2021年第63卷第4期

页      面：210-215页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 10[医学] 

基　　金：financial supports from the National Natural Science Foundation of China(U1608255) 

主　　题：release composite diffusion 

摘      要：Controlled drug release technology is becoming a commercially sound methodology of administering pharmaceutical therapies,and it is important to predict and control the release kinetics to fully take advantage of this ***(CMCS)and alginate(SA)blend membranes were successfully prepared by solution casting technique and exposing to acetic acid atmosphere,which induced the protonation of the amino groups of CMCS,and the formation of polyelectrolyte composite *** using diclofenac diethylamine as the model drug,the diffusion controlled drug release behaviors of the membranes were studied based on permeation experiment,which indicated that the swelling rates of the membranes could be adjusted by simply changing the weight ratio of CMCS/SA and effectively changed the release rate of the *** study shows that CMCS/SA blend membranes are promising biomaterials used for modulating the permeation behavior and developing advanced drug delivery systems.