Fatty liver disease:Disparate predictive ability for cardiometabolic risk and all-cause mortality

作     者：Altan Onat Günay Can Aysem Kaya Tugba Akbas Fatma Ozpamuk-Karadeniz Baris Simsek Hakan Cakir Hüsniye Yüksel 

作者机构：Department of CardiologyCerrahpasa Medical FacultyIstanbul University Department of Public HealthCerrahpasa Medical FacultyIstanbul University Section of BiochemistryInstitute of Cardiologyall Istanbul University Bagcilar Educational Hospital Balikligol State Hospital Department of CardiologyS.Ersek Center for Cardiovascular Surgery Darica Farabi State Hospital 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2015年第21卷第48期

页      面：13555-13565页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by automotive company TOFAS Istanbul Turkey 

主　　题：All-cause death Coronary heart disease Hepatic steatosis Metabolic syndrome Turkish adultrisk factor study 

摘      要：AIM: To assess the association of a surrogate of fatty liver disease(FLD) with incident type-2 diabetes, coronary heart disease, and all-cause ***: In a prospective population-based study on 1822 middle-aged adults, stratified to gender, we used an algorithm of fatty liver index(FLI) to identify associations with outcomes. An index ≥ 60 indicated the presence of FLD. In Cox regression models, adjusted for age, smoking status, high-density lipoprotein cholesterol, and systolic blood pressure, we assessed the predictive value of FLI for incident diabetes, coronary heart disease(CHD), and all-cause ***: At a mean 8 year follow-up, 218 and 285 incident cases of diabetes and CHD, respectively, and 193 deaths were recorded. FLD was significantly associated in each gender with blood pressure, total cholesterol, apolipoprotein B, uric acid, and C-reactive protein; weakly with fasting glucose; and inversely with high-density lipoprotein-cholesterol and sex hormonebinding globulin. In adjusted Cox models, FLD was(with a 5-fold HR) the major determinant of diabetes development. Analyses further disclosed significant independent prediction of CHD by FLD in combined gender [hazard ratio(HR) = 1.72, 95% confidence interval(CI): 1.17-2.53] and men(HR = 2.35, 95%CI: 1.25-4.43). Similarly-adjusted models for all-cause mortality proved, however, not to confer risk, except for a tendency in prediabetics and diabetic ***: A surrogate of FLD conferred significant high risk of diabetes and coronary heart disease, independent of some metabolic syndrome traits. Allcause mortality was not associated with FLD, except likely in the prediabetic state. Such a FLI may reliably be used in epidemiologic studies.