Animal models for hepatocellular carcinoma arising from alcoholic and metabolic liver diseases
作者机构：A.W.Morrow Gastroenterology and Liver CentreRoyal Prince Alfred HospitalSydneyNSW 2050Australia Sydney Medical SchoolUniversity of SydneySydneyNSW 2050Australia Liver Injury and Cancer ProgramCentenary InstituteSydneyNSW 2050Australia
出 版 物：《Hepatoma Research》 (肝癌研究（英文版）)
年 卷 期：2020年第6卷第2期
页 面：39-54页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Hepatocellular carcinoma animal models mouse models non-alcoholic fatty liver disease alcohol haemochromatosis
摘 要：Hepatocellular carcinoma (HCC) is a major and increasing cause of clinical and economic burden worldwide. Now that there are effective therapies to control or eradicate viral aetiologies, the landscape of HCC is changing with alcoholic and metabolic liver diseases becoming major catalysts. The pathogenesis of HCC is complex and incompletely understood, hampering improvements in therapy. Animal models are essential tools for advancing study on the cellular and molecular processes in HCC and for screening potential novel therapies. Many models of hepatocarcinogenesis have been established using various methods including genetic engineering, chemotoxic agents and dietary manipulation to direct implantation of tumour cells. However, none of these can accurately replicate all features found in human diseases. In this review, we provide an overview of different mouse models of HCC with a particular focus on cancer arising from alcoholic liver disease, non-alcoholic fatty liver disease and hereditary haemochromatosis. We also highlight their strengths and limitations and provide perspectives for future study.
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