Hematological parameters in high altitude residents:Tibetan natives versus Han migrants

作     者：Tian-yi WU Feng-yun LIU Ling HU Chun-yin WEI Zhi-gang WANG Ouzhou-LOUBU Chao-ying CU Bianba Xue-bin QI Bing SU 

作者机构：Department of Hypoxic Physiology and Mountain SicknessHigh Altitude Medical Research Institute High Altitude Medical Research CentreUniversity of Tibet Department of Hematological LaboratoryQinghai Cardiovascular Disease Hospital State Key Laboratory of Genetic Resources and EvolutionKunming Institute of ZoologyAcademy of Science 

出 版 物：《中国应用生理学杂志》 (Chinese Journal of Applied Physiology)

年 卷 期：2014年第30卷第6期

页      面：516-525页

核心收录：

学科分类：0710[理学-生物学] 083002[工学-环境工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 07[理学] 08[工学] 09[农学] 0903[农学-农业资源与环境] 071007[理学-遗传学] 0713[理学-生态学] 

基　　金：supported by the "973" National Basic Research Program(2012 CB 518202 and "Pre-973" National Basic Research Program(2012 CB 722506) 

主　　题：高海拔地区 西藏高原 血液参数 移民生活 汉族 多元回归方程 血红蛋白 居民 

摘      要：Objective Aim of our study was to compare hematological parameters in Tibetan natives with those in Han migrants living on the Tibet plateau in order to determine the potential effects of age,gender,and ethnicity on hematological response to *** Blood hemoglobin(Hb,g/dl),hematocrit(Hct,%),red blood cells(RBC,10~6/mm^3) were measured in 3 588 healthy Tibetan natives and 3 371 Han migrants ranging in age from 5 to 72 years,living at a mean altitudes of 2 664 m,3 813 m,4 525 m and 5 226 *** Hemoglobin(Hb) concentration analysis was made by multiple regression equations relating hemoglobin to altitude and *** 2 093 Han males,Hb =9.612+ 0.001440xaltitude+ 0.06148 ***1 948 Tibetan males,Hb =12.202+ 0.000462xaltitude+ 0.02893 *** 1 278 Han females,Hb = 10.858+0.000939xaltitude+ 0.02632 *** 1 640 Tibetan females,Hb =11.402+ 0.000626xaltitude+ 0.00412 *** of the four equations was statistically significant(P0.001),and had variance(r2) of 0.86 or more,indicating that altitude and age accounted for at least 85%of the variation in hemoglobin *** coefficients for altitude and for age were higher(P0.05) in Han males than in Tibetan males and higher(P0.05)in Han females than in Tibetan *** Tibetan postmenopausal females had higher Hb values than premenopausal females only presented at altitude above 4 000 m while this phenomenon was beginning at altitude of 2 664 m among Han *** We conclude that gender and increasing age in Tibetans are associated with lower hemoglobin values than those in Han at high altitude,and we speculate that genetic factors seems to be important.