Transition-metal-free synthesis of 1,4-benzoxazepines via[4+3]-cycloaddition of para-quinone methides with azaoxyallyl cations

作     者：Shuang-Jing Zhou Xiao Cheng Chun-Xia Hu Guo-Yong Xu Wen-Jing Xiao Jun Xuan Shuang-Jing Zhou;Xiao Cheng;Chun-Xia Hu;Guo-Yong Xu;Wen-Jing Xiao;Jun Xuan

作者机构：Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials and Key Laboratory of Functional Inorganic Materials of Anhui ProvinceCollege of Chemistry&Chemical EngineeringAnhui UniversityHefei 230601China Key Laboratory of Structure and Functional Regulation of Hybrid Materials(Anhui University)Ministry of EducationHefei 230601China Key Laboratory of Pesticide&Chemical BiologyMinistry of EducationCollege of ChemistryCentral China Normal UniversityWuhan 430079China AInstitute of Physical Science and Information TechnologyAnhui University.Hefei 230601China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2021年第64卷第1期

页      面：61-65页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the National Natural Science Foundation of China(21971001,21702001) the Natural Science Foundation of Anhui Province(1808085MB47) the Open Fund for Discipline Construction Institute of Physical Science and Information Technology Anhui University and the Start-up Grant from Anhui University 

主　　题：1,4-benzoxazepines para-quinone methides azaoxyallyl cations cycloaddition transition-metal-free 

摘      要：A formal[4+3]-cycloaddition reaction of ortho-hydroxyphenyl-substituted para-quinone methides(p-QMs)with in-situ generated azaoxyallyl cations is *** reaction occurs under very mild reaction conditions(transition-metal free,room temperature,cheap inorganic base)and provides a very efficient route to a series of biologically important 1,4-benzoxazepine derivatives in good to excellent yields.