The role of neutrophils in the development of liver diseases
The role of neutrophils in the development of liver diseases作者机构：The Institute of Translational Hepatology Research Center for Biological Therapy Beijing 302 Hospital Beijing China he Institute of Intensive Care Unit Beijing 302 Hospital Beijing China These authors contributed equally to this study
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2014年第11卷第3期
页 面：224-231页
核心收录：
学科分类：08[工学] 0906[农学-兽医学] 09[农学] 0815[工学-水利工程]
基 金：This work was supported by grants from the National Grand Program on Key Infectious Disease the National Science Fund for Outstanding Young Scholars
主 题：liver disease liver injury neutrophil
摘 要：Liver disease encompasses a wide variety of liver conditions, including liver failure, liver cirrhosis and a spectrum of acute and chronic hepatitis, such as alcoholic, fatty, drug, viral and chronic hepatitis. Liver injury is a primary causative factor in liver disease; generally, these factors include direct liver damage and immune-mediated liver injury. Neutrophils （also known as neutrophilic granulocytes or polymorphonuclear leukocytes （PMNs）） are the most abundant circulating white blood cell type in humans, and PMNs are a major innate immune cell subset. Inappropriate activation and homing of neutrophils to the microvasculature contributes to the pathological manifestations of many types of liver disease. This review summarizes novel concepts of neutrophil-mediated liver iniurv that are based on current clinical and animal model studies.
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