Assessment of the Sensitivity and Specificity of the Established Real-time Quaking-induced Conversion(RT-QuIC)Technique in Chinese CJD Surveillance

作     者：XIAO Kang YANG Xue Hua ZOU Wen Quan DONG Xiao Ping SHI Qi XIAO?Kang;YANG?Xue?Hua;ZOU?Wen?Quan;DONG?Xiao?Ping;SHI?Qi

作者机构：State Key Laboratory for Infectious Disease Prevention and ControlCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases(Zhejiang University)National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Center for Global Public HealthChinese Center for Disease Control and PreventionBeijing 102206China Wuhan Institute of VirologyChinese Academy of ScienceWuhan 430071Hubei China 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2020年第33卷第8期

页      面：620-622页

核心收录：

学科分类：0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：Supported by Chinese National Natural Science Foundation Grants National Key Research and Development Project[2016YFC1202700,2017YFC1200500] the State Key Laboratory of Infectious Disease Prevention and Control,China CDC[2019SKLID501 and 2019SKLID603] 

主　　题：diagnosis CJD cerebrospinal 

摘      要：Real-time quaking-induced conversion(RT-QuIC)assay is a newly established PrPSc-detecting *** development of RT-QuIC improves the diagnosis of sporadic Creutzfeldt–Jakob disease(sCJD),showing good sensitivity and specificity in many countries when the method was used in cerebrospinal fluid(CSF)***,in China,the sensitivity and specificity of RT-QuIC has yet to be determined due to the lack of definitive diagnosis samples.