Exercise immunology:Future directions

作     者：David C.Nieman Brandt D.Pence David C.Nieman;Brandt D.Pence

作者机构：Human Performance LaboratoryAppalachian State UniversityNorth Carolina Research CampusKannapolisNC 28081USA School of Health StudiesUniversity of MemphisMemphisTN 38152USA 

出 版 物：《Journal of Sport and Health Science》 (运动与健康科学（英文）)

年 卷 期：2020年第9卷第5期

页      面：432-445页

核心收录：

学科分类：0403[教育学-体育学] 040302[教育学-运动人体科学(可授教育学、理学、医学学位)] 04[教育学] 1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 

主　　题：Exercise Immunology Lipidomics Metabolomics Proteomics 

摘      要：Several decades of research in the area of exercise immunology have shown that the immune system is highly responsive to acute and chronic exercise training.Moderate exercise bouts enhance immunosurveillance and when repeated over time mediate multiple health benefits.Most of the studies prior to 2010 relied on a few targeted outcomes related to immune function.During the past decade,technologic advances have created opportunities for a multi-omics and systems biology approach to exercise immunology.This article provides an overview of metabolomics,lipidomics,and proteomics as they pertain to exercise immunology,with a focus on immunometabolism.This review also summarizes how the composition and diversity of the gut microbiota can be influenced by exercise,with applications to human health and immunity.Exercise-induced improvements in immune function may play a critical role in countering immunosenescence and the development of chronic diseases,and emerging omics technologies will more clearly define the underlying mechanisms.This review summarizes what is currently known regarding a multi-omics approach to exercise immunology and provides future directions for investigators.