Is the neocortex a novel reservoir for adult mammalian neurogenesis?

作     者：Mengqi Zhang Hui Wang Kun Xiong 

作者机构：Clinical Medicine Eight-year Program Xiangya Medical School of Central South University Changsha 410013 Hunan Province China Department of Anatomy and Neurobiology -Xiangya Medical School of Central South University Changsha 410013 Hunan Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2011年第6卷第17期

页      面：1334-1341页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071006[理学-神经生物学] 

基　　金：the National Natural Science Foundation of China,No.30900773 the National University Basic Research Foundation of China,No.2010QZZD022 

主　　题：adult neurogenesis corticogenesis doublecortin neuroplasticity neocortex neuralregeneration 

摘      要：A novel population of cells expressing typical markers of immature neurons, such as doublecortin-positive cells, was recently identified. This population was predominantly located in layer II of the adult cerebral cortex of relatively large mammals. These cells appear to maintain an immature phenotype for a protracted time window, suggesting a lifelong role in cortical plasticity under normal physiological conditions, and possibly under pathological conditions as well. This review discusses recent evidence regarding the detailed features of these unique cells, including their distribution, morphology, fate, temporal and spatial origin, as well as their relevance and possible functions in various physiological and pathological conditions. In addition, we review studies that have produced conflicting results, possibly as a result of discrepancies in the methodology used to detect neurogenesis. In theory, the properties of these cells indicate that they might exert a significant impact on neocortical function, informing potential therapeutic strategies designed to induce endogenous neurogenesis in the treatment of neuropathological diseases.