Cell-SELEX-based aptamer-conjugated nanomaterials for enhanced targeting of cancer cells

作     者：KONG RongMei, CHEN Zhuo, YE Mao, ZHANG XiaoBing & TAN WeiHong State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China 

作者机构：State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2011年第54卷第8期

页      面：1218-1226页

核心收录：

学科分类：1002[医学-临床医学] 0703[理学-化学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Basic Research Program of China (2011CB911000) China National Grand Program on Key Infectious Disease (2009ZX10004-312) National Natural Science Foundation of China (20975034) 

主　　题：碳纳米材料 SELEX 癌细胞 共轭 适体 基础 实验 金属纳米粒子 

摘      要：Early detection and treatment of cancer depends on developing highly sensitive and specific methods for targeting cancer cells. To do this, aptamers, which are generated by a novel technique called cell-SELEX (systematic evolution of ligands by exponential enrichment), have been widely applied in cancer cell targeting based on such merits as high target affinity and specificity, small size, minimal immunogenicity, and ease of chemical modification. Furthermore, aptamers can gain more flexibility as cancer cell targeting tools when conjugated to nanomaterials, including metallic nanoparticles, quantum dots, silica nanoparticles, and carbon nanomaterials, among others. In this review, we discuss the use of cell-SELEX-based aptamer-nanomaterials conjugates as novel molecular tools for enhanced targeting of cancer cells.