Maternal exposure to antibiotics increases the risk of infant eczema before one year of life:a meta-analysis of observational studies
作者机构：Department of DermatologyJingzhou First People's HospitalShashi DistrictNo.8 Hangkong RoadJingzhou 434000China
出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)
年 卷 期：2020年第16卷第2期
页 面：143-151页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 10[医学] 100206[医学-皮肤病与性病学]
主 题：Antibiotics Eczema Infant Meta-analysis
摘 要：Background There are some conflicting evidences showing that maternal exposure to antibiotics may increase the risk of infant eczema.The present study aims to estimate the effect of prenatal antibiotics administration on infant eczema.Methods According to the established inclusion criteria,eligible observational studies were collected by comprehensive database search.The qualities of the included studies were assessed using the Newcastle-Ottawa Scale.Effect sizes that were adjusted by multivariable models were extracted and combined.Publication bias was evaluated by visual inspection of funnel plot.Results A total of seven observational studies were included.The qualities of the included studies were at moderate or high level.Prenatal antibiotics use was positively associated with eczema before one year of age[odds ratio(OR)=1.93,95%confidence interval(CI)1.35-2.76].In addition,antibiotics exposure in utero was likely to be related to eczema after one year of age(OR 1.21,95%CI 0.98-1.49).The exposure to antibiotics during third trimester was not associated with infant eczema(OR0.97,95%CI 0.86-1.09).Conclusions Maternal exposure to antibiotics is associated with eczema by one-year age and may have a prolonged effect on eczema after 1-year age.The influence of timing of antibiotics exposure during pregnancy needs more studies to clarify.
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