In vivo volumetric monitoring of revascularization of traumatized skin using extended depth-of-field photoacoustic microscopy

作     者：Zhongwen CHENG Haigang MA Zhiyang WANG Sihua YANG Zhongwen CHENG;Haigang MA;Zhiyang WANG;Sihua YANG

作者机构：MOE Key Laboratory of Laser Life Science&Institute of Laser Life ScienceCollege of BiophotonicsSouth China Normal UniversityGuangzhou 510631China Guangdong Provincial Key Laboratory of Laser Life ScienceCollege of BiophotonicsSouth China Normal UniversityGuangzhou 510631China 

出 版 物：《Frontiers of Optoelectronics》 (光电子前沿（英文版）)

年 卷 期：2020年第13卷第4期

页      面：307-317页

核心收录：

学科分类：0808[工学-电气工程] 0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0803[工学-光学工程] 0702[理学-物理学] 

基　　金：This work was supported by the National Natural Science Foundation of China(Grant Nos.61822505,11774101,61627827,and 81630046) the Science and Technology Planning Project of Guangdong Province,China(No.2015B020233016) the Science and Technology Program of Guangzhou(No.2019050001) 

主　　题：photoacoustic microscopy(PAM) extended depth-of-field traumatized skin 

摘      要：Faster and better wound healing is a critical medical *** the repair process of wounds is closely related to revascularization,accurate early assessment and postoperative monitoring are very important for establishing an optimal treatment ***,we present an extended depth-of-field photoacoustic microscopy system(E-DOF-PAM)that can achieve a constant spatial resolution and relatively uniform excitation efficiency over a long axial *** superior performance of the system was verified by phantom and in vivo ***,the system was applied to the imaging of normal and trauma sites of volunteers,and the experimental results accurately revealed the morphological differences between the normal and traumatized skin of the epidermis and *** results demonstrated that the E-DOF-PAM is a powerful tool for observing and understanding the pathophysiology of cutaneous wound healing.