Dietary L-citrulline supplementation modulates nitric oxide synthesis and antioxidant status of laying hens during summer season

作     者：Victoria A.Uyanga Hongchao Jiao Jingpeng Zhao Xiaojuan Wang Hai Lin Victoria A.Uyanga;Hongchao Jiao;Jingpeng Zhao;Xiaojuan Wang;Hai Lin

作者机构：Department of Animal ScienceCollege of Animal Science and Veterinary MedicineShandong Provincial Key Laboratory of Animal Biotechnology and Disease ControlShandong Agricultural UniversityNo.61 Daizong StreetTai'an 271018ShandongChina 

出 版 物：《Journal of Animal Science and Biotechnology》 (畜牧与生物技术杂志（英文版）)

年 卷 期：2021年第12卷第2期

页      面：661-676页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 0832[工学-食品科学与工程（可授工学、农学学位）] 090502[农学-动物营养与饲料科学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 0905[农学-畜牧学] 0906[农学-兽医学] 09[农学] 0703[理学-化学] 0836[工学-生物工程] 

基　　金：supported by the National Key Research Program of China(2016YFD0500510) the China Agriculture Research System(CARS-40-K09) National Natural Science Foundation of China(31772619) 

主　　题：Arginine Antioxidants Laying hens L-citrulline Nitric oxide Summer 

摘      要：Background:L-citrulline(L-Cit),a non-protein amino acid,has been implicated in several physiological functions including anti-inflammatory,anti-oxidative,and hypothermic roles,however,there is a paucity of information with regards to its potential in poultry ***:This study was designed to investigate the effects of dietary L-Cit supplementation on the production performance,nitric oxide production,and antioxidant status of laying hens during summer ***-Line Brown laying hens(n=288,34 weeks old)were allotted to four treatment,6 replicates of 12 chickens *** treatments of control(basal diets),0.25%,0.50%and 1.00%L-Cit supplementation were fed to chickens for eight(8)*** performance,free amino acid profiles,nitric oxide production,and antioxidant properties were *** samples were collected at the 4th and 8th weeks of the ***:Air temperature monitoring indicated an average daily minimum and maximum temperatures of 25.02°C and 31.01°C *** supplementation with L-Cit did not influence(P0.05)the production performance,and rectal temperature of laying *** shape index was increased(P0.05)with increasing levels of ***-free content of arginine,citrulline,ornithine,tryptophan,histidine,GABA,and cystathionine were elevated,but taurine declined with L-Cit *** nitric oxide(NOx)concentration was highest at 1%***,nitric oxide synthase(NOS)activity for total NOS(tNOS)and inducible NOS(iNOS)were upregulated with increasing L-Cit levels,although,tNOS was not affected at the 4th ***-oxidant enzymes including catalase and superoxide dismutase(SOD)were increased with L-Cit supplementation,however,SOD activity was unchanged at 4th week,while total anti-oxidant capacity increased at the 8th week.L-Cit supplementation attenuated the extent of lipid peroxidation,and also inhibited glutathione peroxidase ***:Dietary L-Cit supplementation modulated systemi