Effects of pHGF on Hepatocyte DNA Synthesis after Partial Hepatectomy in Rats

作     者：唐望先 梁扩寰 王俊平 杜荔菁 张文英 TANG Wangxian;LIANG Kuohuan;WANG Junping;DU Lijing;ZHANG Wenying (Institute of Liver Diseases, Tongji Hospital, Tongji Medical University, Wuhan 430030)

作者机构：Institute of Liver Diseases Tongji Hospital Tongji Medical University Wuhan 

出 版 物：《Journal of Huazhong University of Science and Technology(Medical Sciences)》 (华中科技大学学报（医学英德文版）)

年 卷 期：1998年第18卷第1期

页      面：25-27页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学] 

主　　题：partial hepatectomy DNA flow cytometry 

摘      要：The effects of pHGF on the changes of hepatocyte proliferative cycle and liver regenerative capacity after partial hepatectomized rats were observed by flow cytometry (FCM). The results were as follows:1)S phase fraction (SPF) in group of normal rats (group A) accounted for 9. 89% and increased gradually within 6 h, following a peak at 12th h or 36th h after operation, but in the group of pHGF-treated rats (group B) the peak appeared at 24th h after operation; 2 )Proliferatioll index (PI) of group A was 19. 6 % before partial hepatectomy, increased to 34. 91% within 6 h and reached a peaks at 12th or 36th h after operation, and in group B the peak appeared at 48th h after operation. There were significant differences between two groups in SPF and PI (P0. 01). The weight of liver began to increase 12 h after operation, and almost reached the preoperative weight 5 days after operation. These findings suggest that PHGF can promote the DNA synthesis and segmentation of hepatocyte.