Evinacumab for Homozygous Familial Hypercholesterolemia

作     者：Frederick J Raal 

出 版 物：《四川生理科学杂志》 (Sichuan Journal of Physiological Sciences)

年 卷 期：2020年第3期

页      面：338-338页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

摘      要：Background: Homozygous familial hypercholesterolemia is characterized by premature cardiovascular disease caused by markedly elevated levels of low-density lipoprotein(LDL) *** disorder is associated with genetic variants that result in virtually absent(null-null) or impaired(non-null) LDL-receptor ***-of-function variants in the gene encoding