Motility index measured by magnetic resonance enterography is associated with sex and mural thickness

作     者：Sven Mansson Olle Ekberg Bodil Ohlsson 

作者机构：Medical Radiation PhysicsDepartment of Translational MedicineLund UniversitySkåne University Hospital MalmöMalmö20502Sweden Department of Translational MedicineDiagnostic RadiologyLund UniversitySkåne University HospitalMalmö20502Sweden Department of Internal MedicineSkåne University HospitalLund UniversityMalmöS-20502Sweden 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2020年第26卷第36期

页      面：5484-5497页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：the Development Foundation of Region Skåne,No.REGSKANE-619091 the Foundation of Skåne University Hospital,No.2017-008 and the Dir Albert Påhlsson’s Foundation,No.2019 

主　　题：Dysmotility Gastrointestinal symptoms Magnetic resonance enterography Motility index Mural thickness Small bowel 

摘      要：BACKGROUND Recently,a technique has been developed to use magnetic resonance enterography(MRE)for the evaluation of small bowel *** hypothesis was that assessment of the motility index(MI)should reflect differences in motility between clinical *** To aim of the present observational,cross-sectional study was to evaluate the use of the MI in daily clinical *** All consecutive patients aged 18-70 years who were referred for MRE at the Department of Radiology during a 2-year period were asked to *** volunteers were included as *** was prepared and conducted in accordance with clinical *** the day of examination,all the participants had to complete the visual analog scale for irritable bowel syndrome(IBS)and IBS-symptom severity *** of MI were calculated from dynamic MR *** was used to evaluate differences in MI between groups,classified as healthy,Crohn’s disease,ulcerative colitis,IBS,other assorted disorders and *** and linear regression were applied to the MI *** medical records were scrutinized for medical *** In all,224 examinations were included(inclusion prevalence 76.3%),with 22 controls and 202 *** was a significant difference in the MI of the jejunum(P=0.021)and terminal ileum(P=0.007)between the different *** MI was inversely associated with the mural thickness of the terminal ileum in men(P0.001)and women(P=0.063)after adjustments,and tended to be lower in men than in women(P=0.056).Subjectively observed reduction of motility on MRI was accomplished by reduced MI of terminal ileum in men(P0.001)and women(P=0.030).In women,diarrhea was inversely associated with the MI of the jejunum(P=0.029),and constipation was positively associated with the MI of the terminal ileum(P=0.039).CONCLUSION Although MIs differ across diseases,a lower MI of the terminal ileum is mainly associated with male sex and an increased mural thickness.S