Effect of osteoporosis and intervertebral disc degeneration on endplate cartilage injury in rats

作     者：Lei Wang Wei Cui Jean Pierre Kalal Tom Van Hoof Bao-Ge Liu 

作者机构：Department of OrthopaedicsBeijing Tiantan Hospital affiliated to Capital Medical University Department of NeurosurgeryUniversity HospitalUniversity of GhentBelgium Department of Human AnatomyEmbryologyHistology and Medical PhysicsUniversity of GhentBelgium 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2014年第7卷第10期

页      面：796-800页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by National Science Foundation.Grant No.81171764 

主　　题：Osteoporosis Intervertebral disc degeneration Vertebral bodies Cartilage endplate Damage 

摘      要：Objective:To investigate the effect of osteoporosis and intervertebral disc degeneration on the endplate cartilage injury in ***:A total of 48 female Sprague Dawley rats(3 months)were randomly divided into Groups A,B,C and D with 12 rats in each *** and intervertebral disc degeneration composite model,simple degeneration model and simple osteoporosis model were prepared in Groups A,B and C *** modeling,four rats of each group at 12th.18th and 24th week were sacrificed,Intervertebral height of cervical vertebra C6/C7 was ***-CT was used to image the endplate of cephalic and caudal cartilage at C6/C7 intervertebral *** area rate of C6 caudal and C7 cephalic cartilage endplate was calculated,and then C6/C7 intervertebral disc was routinely embedded and *** with safranin O to observe histological changes ***:At 12,18 and24 weeks,intervertebral disc height of C6/C7 were(0.58±0.09)mm,(0.53±0.04)mm and(0.04±0.06)mm in Group A rats,(0.55±0.05)mm,(0.52±0.07)mm and(0.07±0.05)mm in Group B *** 24th *** disc height of Group A rats was significantly lower than that of Group B rats(P0.05).At 12 and 18 weeks,the abraded rate of C6 caudal and C7 cephalic cartilage endplate in Group A rats were significantly higher than that in Groups B.C and D rats(P0.05).Microscopic observation of CT showed that ventral defects in C6caudal or C7 cephalic cartilage endplate in Groups A and B appeared after 12 weeks of modeling;obvious cracks were found in front of the C6 and C7 vertebral body,and cartilage defect shown the trend ofrepairingat 18 and 24 weeks a