Pressure control strategies in biosafety level-3 large-scale production facilities for animal vaccines

作     者：Lei Liang Xin Feng Yi Li 

作者机构：China Academy of Building ResearchBeijing 100013China 

出 版 物：《Biosafety and Health》 (生物安全与健康（英文）)

年 卷 期：2020年第2卷第3期

页      面：124-129页

学科分类：090603[农学-临床兽医学] 09[农学] 0906[农学-兽医学] 

基　　金：supported and financially funded by the National Key R&D Program of China:Source identification monitoring and integrated control of indoor microbial contamination(No.2017YFC0702800) 

主　　题：BSL-3 facility Large scale production Working condition conversion Negative pressure Animal vaccine 

摘      要：This paper summarized the pressure control methods used in 16 large-scale production facilities in China for vaccines against foot-and-mouth disease virus and highly pathogenic avian influenza *** presented the pressure control modes,with their characteristics,of theconstant supplymode-variable exhaust air volume system and theconstant supplymode-constant exhaust air volume *** paper analyzed the influence of common problems(e.g.,pressure reference zero drift,positive pressure reversal and failure to restore the original normal working conditions after working condition conversion)on system stability during pressure control in BSL-3 large-scale production facilities and their solutions,providing references for the design and implementation of similar construction projects under the new situation.