Automated recommendation of the seasonal influenza vaccine strain with PREDAC

作     者：Yousong Peng Aiping Wu Jing Meng Lei Yang Dayan Wang Yuelong Shu Taijiao Jiang 

作者机构：Center for Systems MedicineInstitute of Basic Medical SciencesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China College of BiologyHunan Provincial Key Laboratory of Medical VirologyHunan UniversityChangsha 410082China Institute of Basic Medical SciencesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China National Institute for Viral Disease Control and PreventionChina CDCBeijing 102206China School of Public Health(Shenzhen)Sun Yat-sen UniversityShenzhen 510275China Suzhou Institute of Systems MedicineSuzhou 215123China 

出 版 物：《Biosafety and Health》 (生物安全与健康（英文）)

年 卷 期：2020年第2卷第3期

页      面：117-119页

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 0836[工学-生物工程] 10[医学] 

基　　金：supported by the Chinese Academy of Medical Sciences(2016-I2M-1-005) the National Key Research and Development of China(2016YFD0500300 and 2016YFC1200200) the National Natural Science Foundation of China(31671371) 

主　　题：Influenza Vaccine recommendation Bioinformatics Antigenic variation Web server 

摘      要：Vaccination is currently the most effective way to protect against influenza *** study presents PREDAC(PRE-Dict Antigenic Cluster),a sequence-based computational method to model antigenic clusters of influenza *** could improve vaccine recommendations for influenza viruses and has been used to support the influenza vaccine strain recommendations at the Chinese National Influenza ***,a PREDAC server which includes tools for the prediction of antigenic variants and antigenic clusters of both influenza A and B viruses was built and made publicly available at http://***/home/.PREDAC could not only facilitate systematic studies of the antigenic evolution of influenza viruses but also provide user-friendly tools for vaccine strain recommendations for influenza viruses.