Glial-derived transforming growth factor β1(TGF-β1):a key factor in multiple sclerosis neuroinflammation

作     者：Coram Guevara Fernando C.Ortiz Coram Guevara;Fernando C. Ortiz

作者机构：Mechanisms of Myelin Formation and Repair LaboratoryInstituto de Ciencias BiomédicasFacultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第3期

页      面：510-511页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the VRIP-UA Ph D fellowship supported by Fondo Nacional de Desarrollo Científico y Tecnológico(FONDECYT)11160616 and DIUA166-2019(VRIP-UA)to FCO 

主　　题：inflammation degeneration sclerosis 

摘      要：Glial cell activation and neuroinflammation in multiple sclerosis(MS):MS is an irreversible and progressive central nervous system(CNS)disease which originates in the autoimmune attack of lymphocytes against CNS *** specialized membrane,synthesized by oligodendrocytes(OL)in the CNS,provides metabolic support to axons and allows for saltatory conduction in *** lack of myelin(i.e.,demyelination)leads to axonal degeneration,neuronal death,and the consequent neurological disabilities(Franklin and Ffrench-Constant,2017).