Rhinocerebral mucormycosis caused by Rhizopus oryzae in a patient with acute myeloid leukemia: A case report

作     者：Ya-Hui Feng Wen-Wen Guo Ya-Ru Wang Wen-Xia Shi Chen Liu Dong-Mei Li Ying Qiu Dong-Mei Shi 

作者机构：Department of Clinical MedicineJining Medical UniversityJining 272067Shandong ProvinceChina Department of HematologyJining No.1 People’s HospitalJining 272067Shandong ProvinceChina Department of DermatologyJining No.1 People’s HospitalJining 272067Shandong ProvinceChina Laboratory of Clinical MycologyJining No.1 People’s HospitalJining 272067Shandong ProvinceChina Medical CenterGeorgetown UniversityWashingtonDC 20057United States Laboratory of Medical MycologyDepartment of DermatologyJining No.1 People’s HospitalJining 272067Shandong ProvinceChina 

出 版 物：《World Journal of Dermatology》 (世界皮肤病学杂志)

年 卷 期：2020年第8卷第1期

页      面：1-9页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：National Natural Science Foundation of China,No.81773337 Medical and Health Science Technology Project of Shandong Province,No.2017WS345 and Traditional Chinese Medicine Science and Technology Development Plans of Shandong Province,No.2017-415 

主　　题：Mucormycosis Rhinocerebral mucormycosis Rhizopus oryzae Acute myeloid leukemia Amphotericin B Droplet digital polymerase chain reaction Case report 

摘      要：BACKGROUND Rhinocerebral mucormycosis(RCM)is a rare fatal fungal infection which is on the increase among immunocompromised hosts such as patients who have had hematological cancers,or have received immunosuppressive drugs,corticosteroids,or other T cell suppressing *** SUMMARY We report a case of RCM caused by Rhizopus oryzae,one of the most common opportunistic pathogens,in a patient suffering from a fourth relapse of acute myeloid *** patient developed RCM after he had received long-term antibiotic agents and *** pathogen was isolated three times from nasal secretions collected from the deep parts of the nasal cavity and was identified by morphology and internal transcribed spacer *** infection was excluded by droplet digital polymerase chain reaction and blood *** patient was empirically treated with caspofungin and voriconazole for several days while the lesions continued to *** patient was given amphotericin B in combination with caspofungin after RCM was suspected,and the lesions improved over the course of treatment,which lasted several ***,the patient eventually died of the primary *** This case indicates that immunosuppressive drugs,including corticosteroids and antimetabolites in hematological tumor,do increase the risk of infections of this *** diagnosis,prompt and frequent surgical debridement,and treatment with amphotericin B without delay are all essential in combatting RCM.