Diagnosis and management of brain metastases:an updated review from a radiation oncology perspective
作者机构：Instituto Mexicano del Seguro Social(IMSS)Departamento de Radio-OncologíaCentro Médico Nacional de OccidenteUniversidad de GuadalajaraGuadalajara 44340México Instituto Mexicano del Seguro Social(IMSS)Departamento de Anatomía PatológicaCentro Médico Nacional de OccidenteUniversidad de GuadalajaraGuadalajara 44340México Instituto Mexicano del Seguro Social(IMSS)Departamento de Física MédicaCentro Médico Nacional de OccidenteGuadalajara 44340México
出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)
年 卷 期：2019年第4卷第7期
页 面：12-27页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Brain metastases whole-brain radiation therapy stereotactic radiosurgery graded prognostic assessment
摘 要：Brain metastasis are the most common intracranial malignancy in the adult population. Their incidence has increased dramatically over the last 20 years, as a result of the increasing number of cases stemming from lung and breast cancer together with the higher cancer survival rates due to diagnostic and therapeutic advances. More than 40%of cancer patients develop brain metastases during the course of their disease: specifically, they appear in 50%of patients with lung cancer, more than 25% of patients with breast cancer, and 20% of patients with melanoma. Diagnosis is made using different imaging approaches, such as computed tomography and magnetic resonance imaging, accompanied by clinical manifestations and a history of malignancy supporting the diagnosis of a brain metastasis. Current treatment options should be oriented to the patient s current performance, the number of intracranial and extracranial lesions, and related factors. Although surgical resection and whole-brain radiotherapy have been standard treatments for many years, numerous treatment modalities have become more easily available and accepted worldwide, producing more favorable and reliable results. Among these is stereotactic radiosurgery, and the latest clinical trials support this treatment.
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