Lipidomics in non-alcoholic fatty liver disease

作     者：Sofia Kartsoli Christina E Kostara Vasilis Tsimihodimos Eleni T Bairaktari Dimitrios K Christodoulou 

作者机构：Department of GastroenterologySchool of Health SciencesFaculty of MedicineUniversity of IoanninaIoannina 45110Greece Laboratory of Clinical ChemistrySchool of Health SciencesFaculty of MedicineUniversity of IoanninaIoannina 45110Greece Department of Internal MedicineSchool of Health SciencesFaculty of MedicineUniversity of IoanninaIoannina 45110Greece 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2020年第12卷第8期

页      面：436-450页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Lipidomics Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Lipotoxicity Fatty acids Ceramides 

摘      要：Non-alcoholic fatty liver disease(NAFLD),the most common chronic liver disorder in Western countries,comprises steatosis to nonalcoholic steatohepatitis(NASH),with the latter having the potential to progress to *** transition from isolated steatosis to NASH is still poorly understood,but lipidomics approach revealed that the hepatic lipidome is extensively altered in the setting of steatosis and steatohepatitis and these alterations correlate with disease *** data suggest that both quantity and quality of the accumulated lipids are involved in pathogenesis of *** in glycerophospholipid,sphingolipid,and fatty acid composition have been described in both liver biopsies and plasma of patients with NAFLD,implicating that specific lipid species are involved in oxidative stress,inflammation,and cell *** this article,we summarize the findings of main human lipidomics studies in NAFLD and delineate the currently available information on the pathogenetic role of each lipid class in lipotoxicity and disease progression.