前列腺素E1对原发性肾病综合征作用初探(英文)

作     者：周巧玲 成小苗 欧阳春 解勤之 陈立平 胡杨清 

作者机构：中南大学湘雅医院肾内科长沙410008 

出 版 物：《中国医学工程》 (China Medical Engineering)

年 卷 期：2002年第10卷第6期

页      面：37-39页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：This work is supported by grant from Beijing Tide Pharmaceutical Co Ltd 

主　　题：Primary Nephrotic Syndrome Prostaglandin E1 Platelet Aggregation Function 

摘      要：Objective:To investigate the effect of prostaglandin E1 (PGE1) (Alprostadii injection) on patients with primary nephrotic syndrome(PNS). Methods: 37 patients with PNS were recruited to study the effect of prostaglandin E1 on platelet aggregation function [ PAG (5,) PAG( m ) ], serum total protein (TP) , albumin (Al),blood urea nitrogen(BUN) ,serum creatinine(Scr) ,cholesterol(CHO), triglyceride(TG), protein in 24-hour urine (Pr/24h) and platelet account (PLT). Results: TP, Al, CHO, TG, BUN, Scr, Pr/24h, PAG(5) and PAG(m) in PNS group before treatment were significantly different from those in control group(P0.05, P0.01) while no significant difference was found for PLT. When treated with PGE1 , TP,Al,CHO, TG, Pr/24h, ADP- induced PAG(5) ,and Adr- induced PAG(5) and PAG(m) were significantly different from those before treatment (P0.05). Adr- induced PAG(5) and PAG(m) were significantly different. Adr- induced PAG(5) was xsitively correlated with BUN and Scr in PNS(P0.01). Similar correlation was found between ADP-induced PAG(5) and Al ,BUN,Scr,Pr/24h(P0.05), AD- induced PAG(m) and TP,CHO(P0.05). Conclusions: PGE1 may be an effective drug for the treatment for hypercoagulation in patients with PNS.