青光眼成本效益分析:影响功用的因素-来自瑞典的初步研究

作     者：Kobelt G. Jonsson B. Bergstrm A. 杨秀梅 

作者机构：European Health EconomicsDannemoragatan 16 A113 44 StockholmSweden 

出 版 物：《世界核心医学期刊文摘（眼科学分册）》 (Digest of the World Core Medical Journals:Ophthalmology)

年 卷 期：2006年第2卷第9期

页      面：53-54页

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

主　　题：青光眼患者 成本效益分析 多元逐步回归分析 初步 瑞典 视力丧失 平均年龄 多元回归分析 

摘      要：Purpose:To investigate the effect of different levels of visual field defect in glaucoma on utilities and to test if utilities could be assessed using a general questionnaire such as the ***:cross-sectional study in 199 patients with ocular hypertension or open-angle glaucoma grouped into 5 severity stages according to visual field defects was performed in 4 specialized ophthalmic *** analysis was performed for the sample and by stage,and the effect of vision loss on utility was investigated with multiple step-wise regression ***:The mean age of the sample was 70 and the mean MD in the worse eye was-13.1 dB(SD 10.2).Visual acuity(VA)was 0.63 and 0.87 in the worse and better eye,respectively,and the mean utility was 0.80(SD 0.23).Utility decreased with increasing glaucomatous damage,ranging from 0.84 for mild disease to 0.72 for severe damage(MD-2.5 to-28.1),but the difference between the groupswas not statistically significant when controlling for co-morbidity,except for the most severe stage(p 0.01).In multiple regression analysis,visual field in the better eye was significantly correlated with utility,and therewas an indirect correlation between visual field in the worse eye and utility:the effect of total VA on utility was significant,and MD in the worse eye was correlated with total ***:Utility is strongly correlated with overall *** results suggest a relationship between glaucomatous damage and utility,and patients with severe damage have a significantly lower ***,this should be further investigated in larger samples that include more patients with moderate-severe bilateral damage.