Cognitive impairment in multiple sclerosis: lessons from cerebrospinal fluid biomarkers

作     者：Lorenzo Gaetani Nicola Salvadori Elena Chipi Lucia Gentili Angela Borrelli Lucilla Parnetti Massimiliano Di Filippo Lorenzo Gaetani;Nicola Salvadori;Elena Chipi;Lucia Gentili;Angela Borrelli;Lucilla Parnetti;Massimiliano Di Filippo

作者机构：Section of NeurologyDepartment of MedicineUniversity of PerugiaPerugiaItaly 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第1期

页      面：36-42页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

主　　题：biomarkers cerebrospinal fluid cognitive impairment information processing speed memory multiple sclerosis 

摘      要：Cognitive impairment is a common clinical manifestation of multiple sclerosis,but its pathophysiology is not completely understood.White and grey matter injury together with synaptic dysfunction do play a role.The measurement of biomarkers in the cerebrospinal fluid and the study of their association with cognitive impairment may provide interesting in vivo evidence of the biological mechanisms underlying multiple sclerosis-related cognitive impairment.So far,only a few studies on this topic have been published,giving interesting results that deserve further investigation.Cerebrospinal fluid biomarkers of different pathophysiological mechanisms seem to reflect different neuropsychological patterns of cognitive deficits in multiple sclerosis.The aim of this review is to discuss the studies that have correlated cerebrospinal fluid markers of immune,glial and neuronal pathology with cognitive impairment in multiple sclerosis.Although preliminary,these findings suggest that cerebrospinal fluid biomarkers show some correlation with cognitive performance in multiple sclerosis,thus providing interesting insights into the mechanisms underlying the involvement of specific cognitive domains.