Predictive value of alarm symptoms in patients with Rome IV dyspepsia: A cross-sectional study

作     者：Zhong-Cao Wei Qian Yang Qi Yang Juan Yang Xin-Xing Tantai Xin Xing Cai-Lan Xiao Yang-Lin Pan Jin-Hai Wang Na Liu 

作者机构：Department of GastroenterologyThe Second Affiliated HospitalXi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina Department of GastroenterologyXi’an No.3 Hospitalthe Affiliated Hospital of Northwest UniversityXi’an 710018Shaanxi ProvinceChina State Key Laboratory of Cancer BiologyNational Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive DiseasesAir Force Medical UniversityXi’an 710032Shaanxi ProvinceChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2020年第26卷第30期

页      面：4523-4536页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Rome IV Dyspepsia Alarm symptoms Prediction 

摘      要：BACKGROUND No studies have evaluated the predictive value of alarm symptoms for organic dyspepsia and organic upper gastrointestinal(GI)diseases based on Rome IV criteria in the Chinese *** To evaluate the predictive value of alarm symptoms for dyspeptic patients based on Rome IV *** We performed a cross-sectional study of dyspepsia patients who met the inclusion and exclusion criteria at two academic urban tertiary-care centers from March 2018 to January *** demographic data,dyspeptic information,alarm symptoms,lifestyle,examination results,family history and outpatient cost information were *** patients with normal findings on upper GI endoscopy,epigastric ultrasound and laboratory examination and without Helicobacter pylori-associated dyspepsia were classified as functional *** A total of 381 patients were enrolled in the study,including 266 functional dyspepsia patients and 115 organic dyspepsia *** were 24 patients with organic upper GI disease among patients with organic *** found that based on the Rome IV criteria,alarm symptoms were of limited value in differentiating organic dyspepsia and organic upper GI diseases from functional ***(odds ratio(OR)=1.056,P=0.012),smoking(OR=4.714,P=0.006)and anemia(OR=88.270,P0.001)were independent predictors for organic upper GI *** the comparison of epigastric pain syndrome,postprandial distress syndrome and epigastric pain syndrome combined with postprandial distress syndrome,the results showed that there were statistically significant differences in anorexia(P=0.021)and previous visits(P=0.012).The *** number is NCT *** Most alarm symptoms had poor predictive value for organic dyspepsia and organic upper GI diseases based on Rome IV *** screening should not be based solely on alarm symptoms.