Continuous, homogeneous and rapid synthesis of 4-bromo-3-methylanisole in a modular microreaction system

作     者：Pei Xie Kai Wang Jian Deng Guangsheng Luo Pei Xie;Kai Wang;Jian Deng;Guangsheng Luo

作者机构：The State Key Laboratory of Chemical EngineeringDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China 

出 版 物：《Chinese Journal of Chemical Engineering》 (中国化学工程学报（英文版）)

年 卷 期：2020年第28卷第8期

页      面：2092-2098页

核心收录：

学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 081702[工学-化学工艺] 0817[工学-化学工程与技术] 08[工学] 0703[理学-化学] 

基　　金：financial support from National Key R&D Program of China(2017YFB0307102) National Natural Science Foundation of China(21991100,21991104) 

主　　题：4-bromo-3-methylanisole bromination continuous synthesis modular microreaction system mixing enhancement 

摘      要：4-Bromo-3-methylanisole is mainly used to synthesize black fluorane dye(2-anilino-3-methyl-6-dibutylaminofluorane, ODB-2), which is one of the most important heat and pressure-sensitive dyes in the manufacture of thermal papers. Compared to the industrial heterogeneous batch process, a continuous homogeneous bromination technology in a modular microreaction system has been developed, and 4-bromo-3-methylanisole has been successfully prepared through high-selective mono-bromination of 3-methylanisole with Br2 solution in CHCl3. In optimal conditions, the content of bis-brominated byproducts can be controlled less than 0.5%,which is superior to the industrial standard with 99.5% 3-methylanisole conversion at very short residence time and mild reaction temperature.