Voxel-based analysis of brain microstructural diffusion indices changes in Parkinson disease with freezing of gait

作     者：Jing-Wu Chen Fa-Ze Mai Yong-Zhe Yang Wan-Qun Yang Li-Juan Wang Kun Nie Biao Huang Chen Jing-Wu;Mai Fa-Ze;Yang Yong-Zhe;Yang Wan-Qun;Wang Li-Juan;Nie Kun;Huang Biao

作者机构：Department of RadiologyThe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510260China Department of RadiologyHainan General HospitalHaikouHainan 570311China School of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China Department of RadiologyGuangdong Academy of Medical SciencesGuangdong Provincial People's HospitalGuangzhouGuangdong 510080China Department of NeurologyGuangdong Academy of Medical SciencesGuangdong Provincial People’s HospitalGuangzhouGuangdong 510080China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2021年第134卷第2期

页      面：249-251页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by grants from the Key R&D Program of Guangdong Province,China(No.2018B030339001) the National Natural Science Foundation of China(No.81671275) 

主　　题：impaired indices diffusion 

摘      要：To the Editor:Freezing of gait(FOG)is a common disabling movement disorder in Parkinson disease(PD),affecting approximately 50%to 80%of PD patients in their late *** can cause the patients to fall easily,seriously affects their quality of life and exerts both economic and emotional *** the common motor symptoms of PD(such as bradykinesia,tremor,or rigidity),FOG is seldom improved by dopaminergic medication therapy or deep brain ***,FOG may be resistant to(or even worsened by)levodopa.[1]However,cognitive training has showed it can reduce the severity of FOG.[2]These findings imply that FOG may be caused not only by motor impairment but also by cognitive *** is reasonable to hypothesize that FOG+patients have impaired cognitive function and that the diffusion indices of the cerebral territories’microstructures associated with cognition are *** test this hypothesis,we applied whole-brain voxel-based analysis(VBA),a fully automated whole-brain analysis that uses voxel-wise statistics on diffusion metrics,to investigate the diffusion indices of brain microstructures changes in FOG+patients,PD patients without FOG(FOG-patients),and healthy controls(HCs).