Potential of kynurenine metabolites in drug development against neurodegenerative diseases

作     者：Lenka Kubicova Vladimir Chobot Lenka Kubicov;Vladimir Chobot

作者机构：Division of Molecular Systems BiologyDepartment of Ecogenomics and Systems BiologyFaculty of Life SciencesUniversity of ViennaViennaAustria 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第2期

页      面：308-309页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：funded by Austrian Science Fund(FWF) grant No.P 24630-B21(to VC) 

主　　题：Figure assumed utilized 

摘      要：Reactive oxygen species(ROS)and kynurenines:Kynurenines represent a relatively heterogenous group of tryptophan metabolites(Figure 1 A).The amino acid tryptophan is metabolized in the humans by the kynurenine or serotonin *** a long time,the kynurenine pathway was assumed primarily to constitute the source for nicotinamide-adenine dinucleotide phosphate,one of the most utilized redox active enzyme cofactors.