Influence of in vitro Methods, Receptor Fluids on Percutaneous Absorption and Validation of a Novel in vitro Method
Influence of in vitro Methods, Receptor Fluids on Percutaneous Absorption and Validation of a Novel in vitro Method作者机构：Laboratory of Skin Physiology and Toxicology School of Public Health Shanghai Medical University China.
出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)
年 卷 期：1994年第7卷第3期
页 面：248-258页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学]
主 题：Receptor Fluids on Percutaneous Absorption and Validation of a Novel in vitro Method Influence of in vitro Methods
摘 要：In vitro experiment using excised skin has been valuable for studying the mechanism of percutaneous absorption. Based on previously established static diffusion cell system in this laboratory, a novel model-peifused glass diffusion cell system is desboed. The results of initial comporative study on percutaneous absorption between glass perfused diffusion cell and static diffusion cell, ih vitro and in vivo permeation as well as factors affecting permeation with seven radiolabelled chemicals are presented. The results demonstrate that the peifused diffusion cell system, which used a perfusion nuid betow the suiface of skin to take up the materials which penetrated the skin, is more similar to physiologic condition,convenient and automatic than that of the static cell. It well predicts the in vivo percutaneous absorption if appropriate areptor fluid is chosen. The results also show that the selection of receptor fluid is critical for in vitro permeation of chemicals with different soubility
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