Stem cell therapy for retinal diseases
为网膜的疾病的干细胞治疗作者机构：Department of Ophthalmology Universidade Federal de Goias Goiania 74001-970 Brazil Department of Ophthalmology Universidade Federal de Sao Paulo Sao Paulo 04023-062 Brazil
出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)
年 卷 期：2015年第7卷第1期
页 面：160-164页
核心收录：
学科分类：10[医学]
主 题：Macular degeneration Human embryonic stem cell Induced pluripotent stem cell Retinal pigment epithelium Stargardt's disease
摘 要：In this review, we discuss about current knowledge about stem cell(SC) therapy in the treatment of retinal degeneration. Both human embryonic stem cell and induced pluripotent stem cell has been growth in culture for a long time, and started to be explored in the treatment of blinding conditions. The Food and Drug Administration, recently, has granted clinical trials using SC retinal therapy to treat complex disorders, as Stargardt s dystrophy, and patients with geographic atrophy, providing good outcomes. This study s intent is to overview the critical regeneration of the subretinal anatomy through retinal pigment epithelium transplantation, with the goal of reestablish important pathways from the retina to the occipital cortex of the brain, as well as the differentiation from pluripotent quiescent SC to adult retina, and its relationship with a primary retinal injury, different techniques of transplantation, management of immune rejection and tumorigenicity, its potential application in improving patients vision, and, finally, approaching future directions and challenges for the treatment of several conditions.
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